INS and hydrops fetalis: Insulin levels in HF-fed rats were significantly higher than in the chow control group at 15 (chow 683 ± 201 versus HF 2597 ± 330 pg/mL, p < 0.0001) and 30 min (chow 542 ± 91 versus HF 1711 ± 247 pg/mL, p < 0.0001).