STAT3 and hyper-IgE syndrome: For instance, at the αB’6 site, patients with STAT3 Asn647Asp [36,72] exhibit symptoms of AD-HIES, but the Asn647Ile [57,65,67] mutation results in STAT3 hyperactivation manifesting as chronic lymphoproliferative disorder of NK cells (CPLD-NK) and T-LGLL.