Interestingly, the application of anti-OX40 stimulatory compounds (MEDI6383 or MEDI6469) was shown to induce activation and proliferation of T cell populations in cancer patients [91], but also resulted in upregulation of PD-L1 in tumor cells, occurring between 12 and 19 days following the infusion (NCT02274155). The gene discussed is CD274; the disease is cancer.