Glutathione S-Transferase Omega 1 (GSTO1), Sulfotransferase Family 2B Member 1 (SULT2B1), ADH1A, ADH1B, and ADH1C were downregulated in lung cancer versus normal tissue, while ALDH3A2 and MTHFD2 were upregulated in lung cancer tissue versus normal adjacent tissue. The gene discussed is ALDH3A2; the disease is lung carcinoma.