Glutathione S-Transferase Omega 1 (GSTO1), Sulfotransferase Family 2B Member 1 (SULT2B1), ADH1A, ADH1B, and ADH1C were downregulated in lung cancer versus normal tissue, while ALDH3A2 and MTHFD2 were upregulated in lung cancer tissue versus normal adjacent tissue. This evidence concerns the gene MTHFD2 and lung cancer.