They concluded that ASR is a rare complication whose cause could be divided amongst six major groups; 1) neoplastic (acute myeloid leukemia, chronic lymphocytic leukemia, lung cancer, etc.), 2) infectious (cytomegalovirus, human immunodeficiency virus, endocarditis, etc.), 3) inflammatory (pancreatitis, rheumatoid arthritis, systemic lupus erythematosus, etc.), 4) drug related (granulocyte-colony stimulating factor, anticoagulation drugs, thrombolytic drugs, etc.), 5) mechanical (pregnancy related, congestive splenomegaly), and 6) idiopathic. The gene discussed is CSF3; the disease is B-cell chronic lymphocytic leukemia.