MSR1 and neoplasm: Although we cannot exclude the possibility that failure to detect SR-A in nodal CHL results from a failure to induce SR-A during macrophage differentiation, it seems unlikely because TAMs in extra-nodal CHL, TAMs in other tumors, and resident tissue macrophages all express SR-A indicating that such a mechanism would be unique to TAMs in the tumor microenvironment of nodal CHL.