In order to further investigate the possibility that decreased abundance of SNARE proteins is implicated in the observed impairment of autophagic clearance in DS cells, FLAG-STX17 or EGFP-VAMP8 were transiently overexpressed in CTL and DS fibroblasts and p62 abundance after serum starvation was measured by immunofluorescence. Here, STX17 is linked to Dravet syndrome.