PCSK9 and Alzheimer disease: For example, using κ = 0.90 or κ = 0.999 instead of 0.99 in PC models (ie, enrolling either 90% or 99.9% of variance in LDL‐C concentrations attributable to genetic variation in the gene region) yielded meta‐analysis effect estimates for PCSK9 inhibition on AD risk of 1.35 (95% CI = 1.09–1.67) and 1.62 (95% CI = 1.41–1.86), respectively.