PBK and lung cancer: TOPK activity is associated with malignancy through multiple kinase pathways: it promotes tumor migration in lung cancer through PI3K/AKT signaling,13 proliferation of breast cancer cell lines through p38 MAPK,19 and chemoresistance in cervical cancer cells through NF‐κB signaling.20 TOPK also directly interacts with p53, inhibiting activation of cell cycle suppressor proteins and leading to aberrant tumor cell proliferation.21, 22