In this study, we showed for the first time the time course of changes in gene expression: α- and β-secretase, presenilin 1 and 2, amyloid protein precursor, and tau protein associated with Alzheimer’s disease in the CA3 area of the hippocampus after 10-min brain ischemia in rats with 2, 7, and 30 days of survival. The gene discussed is PSEN1; the disease is Alzheimer disease.