CASP3 and glioblastoma: As shown in Figure 1F, caspase-3 activity was enhanced via the transfection with sh-DLEU1#1 and sh-DLEU1#3 plasmids in U251 (P<0.01) and LN229 cells (P<0.01), indicating that declined DLEU1 expression induced more GBM cell apoptosis.