As there were no significant correlations between anti-PS IgG antibodies and the other B-cell subsets (naïve, immature, classical memory or plasma cells), or of other antibodies (DNA, PfEBA) with anemia or with atypical memory B-cells, these results suggest specificity and support the hypothesis that atypical T-bet+FcRL5+ memory B-cells secrete anti-PS IgG antibodies that contribute to malarial anemia in P.-falciparum-infected patients. The gene discussed is FCRL5; the disease is anemia (phenotype).