The direct correlation of anti-PS antibodies with levels of LDH [which are increased as a result of erythrocyte lysis during malarial anemia (Sonani et al., 2013; White, 2018)] and with the erythrocyte lysis capacity of the plasma supports the hypothesis that autoimmune anti-PS antibodies contribute to anemia in malaria through complement-mediated lysis. The gene discussed is PRB2; the disease is anemia (phenotype).