Downregulation of miR-16 expression is observed in OSCC patients and cancer cell lines and its lower expression is negatively correlated with overexpression of its target gene Tousled-like kinase 1 (TLK1) and associated with positive LN metastasis, as well as with higher TNM stage and poor prognosis (Hu et al. 2018a). The gene discussed is TLK1; the disease is cancer.