Decreased expression of TET-1 gene occurs also in laryngeal squamous cell carcinoma (LSCC) and is connected with a lower level of 5-hmC, suggesting that the level of 5-hmC is strongly correlated with the level of TET-1 and may be a poor prognostic factor of LSCC patients in an early stage of cancer (Zhang et al. 2016). Here, TET1 is linked to laryngeal squamous cell carcinoma.