AKT3 and lip and oral cavity carcinoma: Other targets genes for miR-16, the oncogenes AKT3 and BCL2L2, may promote cell proliferation and inhibit apoptosis in OSCC cells; oral cancer cell lines show a negative correlation between expression of miR-16 and expression of AKT3 and BCL2L2, confirming a tumor-suppressing role of miR-16 in oral cancer (Wang and Li 2018).