Out of the 18 neutrophil genes analyzed, 9 genes had an expression peak on day 10, including CD11b, CD177, S100a8, S100a9, TLR4, Elastase, MMP9, caspase 1 and TGFβ; 4 genes had a peak of expression on day 14 but was also augmented on day 10, including CD66a, Arginase 1, COX2 and INFγ; the other two genes: CXCR4 had a decreased expression on day 5, and CD274 did not alter in neutrophils during the tumor growth (Fig. 4). Here, MMP9 is linked to neoplasm.