Moreover, it was analyzed the influence of the tumor growth in circulating neutrophil gene expression profile, revealing that blood neutrophils up-regulate the cytokines IL1β and TNFα more expressively in days 5 and 7 of tumor development (Fig. 1) and different pro-inflammatory proteins and surface markers along the 14-day tumor growth (Fig. 4). The gene discussed is IL1B; the disease is neoplasm.