In the multivariable logistic regression model, the relevant factors associated with an increased risk of AKI were SOFA (OR 1.11; 95% CI 1.03–1.19; p = 0.007) and [TIMP-2]∙[IGFBP7] measurement: a 0.1 (ng/ml)2/1000 unit increment was likely to increase the risk of AKI by 2% (p = 0.002, Table 4). The gene discussed is TIMP2; the disease is acute kidney injury.