Our model proposes a warning to the physician upon a patient’s ICU admission, leading to a substantial shortening of the time needed for the intervention (at admission to the ICU and at any stage), suggesting that when [TIMP-2]∙[IGFBP7] is greater than 0.3, an increased risk of AKI may persist up to 7 days. This evidence concerns the gene TIMP2 and acute kidney injury.