[TIMP-2]*[IGFBP7] showed the best performance for severe AKI (stages 2 and 3) within 12 hours: AUC 0.82 (95%CI 0.70–0.88)) and all events of severe AKI up to 7 days (AUC 0.74 (95%CI 0.68–0.81); Figs 1 and 2, Supplementary Table 2S). Here, IGFBP7 is linked to acute kidney injury.