To identify pro-inflammatory condition-specific cytokines expressed in demyelinating SCs, we compared cytokine expression profiles in the neuropathic sciatic nerves of B7-2 knockout NOD (B7-2KO) mice, that show a spontaneous autoimmune demyelinating neuropathy8,16 and injured C57BL/6 nerves (in this case, the innate immunity is activated during WD) with a commercial cytokine expression panel17. This evidence concerns the gene CD86 and Wilson disease.