Clear synergistic effects of romidepsin and JQ1 in terms of apoptosis (PARP1 cleavage and γH2AX induction) (Fig. 7b), cell cycle arrest (p27 induction, MYC downregulation) and plasmatic differentiation (BCL6 downregulation) (Fig. 7c) were observed, indicating that the drugs combination could be effective in aggressive B cells lymphoma. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.