AKT1 and neoplasm: SNARE TKO reduced active AKT and ERK signaling in xenografted tumors driven by oncogenic KRAS and reduced tumor size by the oncogenic KRAS mutant subclone down to that seen with the KRAS WT isogenic line, which still formed tumors of comparable size whether SNAREs were knocked out or not (Fig. 6d–g; Supplementary Fig. 6B).