A complementary analysis of co-essentiality in 340 cancer cell lines in which whole genome CRIPSR KO screening has been performed in the Project Achilles effort also revealed significant and specific SNAP23 – KRAS correlation, suggesting that SNAP23’s functions are especially critical in enabling tumorigenesis driven by KRAS, but not other Ras isoforms (Supplementary Fig. 6G). This evidence concerns the gene SNAP23 and cancer.