KRAS and cancer: A complementary analysis of co-essentiality in 340 cancer cell lines in which whole genome CRIPSR KO screening has been performed in the Project Achilles effort also revealed significant and specific SNAP23 – KRAS correlation, suggesting that SNAP23’s functions are especially critical in enabling tumorigenesis driven by KRAS, but not other Ras isoforms (Supplementary Fig. 6G).