In the cecal ligation and puncture (CLP)-induced sepsis model, MALAT1 expression is significantly upregulated, which in turn aggravates cardiac dysfunction and inflammation by activating p38 MAPK/NF-κB, resulting in increased TNF-α, IL-1β, IL-6, IL-10, IL-17 and IFN-γ. The gene discussed is TNF; the disease is Sepsis.