This followed with decreased proportions of CD8+ T cells (Fig. 1i, m, ANOVA: F(5, 24)= 50.992, P < 0.0001), CD49b+ cells (Fig. 1j, n, ANOVA: F(5, 24)= 104.871, P < 0.0001), and CD4+ T cells (Fig. 1k, o, ANOVA: F(5, 24)= 24.893, P < 0.0001) p.i., while the proportion of splenic B cells significantly increased from day 4 after infection (Fig. 1l, p, ANOVA: F(5, 24)= 35.299, P < 0.0001). This evidence concerns the gene CD4 and infection.