Nevertheless, in a recent study performed using a next-generation sequencing approach on 36 lung adenocarcinomas, BRAFV600E mutations occurred in 28% of the cases, mostly in smokers (90%), and in concomitance with AKT or PIK3CA mutations, non-V600E mutations occurred in 72% of the cases and in concomitance with KRAS mutations in four cases [33]. Here, PIK3CA is linked to lung adenocarcinoma.