SMAD7 and neoplasm: Based on the clinical information for TMA (provided by the U.S. Biomax), we found a negative correlation between tumor grade and SMAD7 expression (p=0.013<0.05), indicating that patients with high-grade liver cancer have lower SMAD7 expression level (Table 1), whereas no significant correlation was found between tumor stage and the expression of SMAD7 expression (p=0.59>0.05; Table 1).