Because the cross-talk between the TGF-β/SMADs and Hippo/YAP signaling pathway has been widely studied [17–19], and, based on the results of our present study and previous several studies that focus on the mechanism of YAP-mediated promotion of liver cancer development [20, 21], we selected the Hippo pathway effector YAP to determine the role of Tan IIA in the regulation of SMAD7 expression in liver cancer. This evidence concerns the gene TGFB1 and liver cancer.