Because the cross-talk between the TGF-β/SMADs and Hippo/YAP signaling pathway has been widely studied [17–19], and, based on the results of our present study and previous several studies that focus on the mechanism of YAP-mediated promotion of liver cancer development [20, 21], we selected the Hippo pathway effector YAP to determine the role of Tan IIA in the regulation of SMAD7 expression in liver cancer. Here, SMAD7 is linked to liver cancer.