A group of single nucleotide polymorphisms in the P2Y12 gene, forming the so called P2Y12 H2 haplotype, has been associated with increased platelet responsiveness to ADP, increased risk of peripheral arterial disease and with coronary artery disease [http://www.ncbi.nlm.nih.gov/pubmed/17803810?dopt=AbstractPlus]. The gene discussed is P2RY12; the disease is peripheral arterial disease.