Knockout of the kcnk5 gene in mice is associated with metabolic acidosis, hyponatremia and hypotension due to impaired bicarbonate handling in the kidney [http://www.ncbi.nlm.nih.gov/pubmed/15141089?dopt=AbstractPlus], as well as deafness [http://www.ncbi.nlm.nih.gov/pubmed/26549439?dopt=AbstractPlus]. The gene discussed is KCNK5; the disease is deafness.