Transfer of naive T cells into the severe combined immunodeficiency (SCID) mice provides a highly reproducible and easily manipulated model of colitis that has characteristics similar to IBD in humans.[26] To assess the net role of CSF-1 in experimental colitis we employed the TCT-colitis model together with a selective inhibitor of CSF-1R kinase, JNJ-40346527. The gene discussed is CSF1; the disease is inflammatory bowel disease.