Of the 14 IPF susceptibility signals (i.e., the 11 previously reported signals weconfirmed and three novel signals), the only variant predicted to have a potentialfunctional effect on gene regulation through disruption of chromatin structure ortranscription factor binding motifs (using DeepSEA) was rs2013701 (in an intron ofFAM13A), which was associated with a change in DNase Ihypersensitivity in 18 cell types and FOXA1 in the T-47D cell line (a breast cancercell line derived from a pleural effusion, Table E4). Here, FOXA1 is linked to medical procedure.