Based on the relevance of these findings for the disease modeling of muscular dystrophies (MD), we then investigated the effect of this small molecule combination on the differentiation and maturation of myotubes derived from a panel of MD patient-specific iPS cells, including two Duchenne Muscular Dystrophy (DMD1 and DMD2), two Myotonic Dystrophy type 1 (DM1-1 and DM1-2) and one LGMD2A (Key resources table) (Magli et al., 2017; Mondragon-Gonzalez and Perlingeiro, 2018; Selvaraj et al., 2019). Here, CAPN3 is linked to muscular dystrophy.