In particular,they found up-regulated gene expression of insulin-likegrowth factor binding protein 1 (IGFBP1), B-cell CLL/Lymphoma 2 (BCL2) and BCL2-associated X protein(BAX), while down-regulated gene expression of IL11,Chemokine (C-C MOTIF) Ligand 4 (CCL4), insulin-likegrowth factor 1 (IGF1) and caspase 8 (CASP8). The gene discussed is CASP8; the disease is B-cell chronic lymphocytic leukemia.