Previous studies reported that tumor‐infiltrating immune cells may represent a crucial pathophysiological factor in the onset and progression of glioma.15 We examined the relationship between COPB2 and six immune cell types that frequently infiltrate the tumor microenvironment, including innate immune cells: neutrophils, tumor‐associated macrophages (TAMs), NK cells, and myeloid‐derived suppressor cells (MDSCs)16, 17 and adaptive immune cells: CD8+T cells and regulatory T cells (Tregs).18, 19 The specific biomarker genes of each immune cell type are displayed in Data S2. The gene discussed is CD8A; the disease is glioma.