Canonical correlation analysis revealed that the transcript levels of COPB2 were positively correlated with the marker gene expression of these six immune cell types in the TCGA datasets (Figure 5B, P < .001), indicating that glioma patients with COPB2‐high were prone to have more immune cells infiltrated than glioma patients with COPB2‐low. This evidence concerns the gene COPB2 and central nervous system cancer.