The coatomer protein complex subunit beta 2 (COPB2), also known as beta prime‐COP or beta‐Cop, is one of the seven subunits that form coatomer complex I.4COPB2 serves as a mediator in the process of protein synthesis which transports proteins from the endoplasmic reticulum (ER) to the Golgi apparatus.5 Recently, COPB2 has been viewed as a new oncogene in many cancer types. This evidence concerns the gene COPB2 and cancer.