Glioma cells could release multiple cytokines that promote the infiltration of various immune cells such as MDSCs, microglia, Tregs, macrophages, CD8 T cells, and CD4 T cells into the tumor microenvironment,22 as tumors not only recruit immune cells, but also transform said cells into phenotypes that can help tumor cells evade immune system surveillance (Table 5). The gene discussed is CD4; the disease is glioma.