Underexpression of COPB2 could downregulate the EMT‐related protein N‐cadherin and vimentin which may promote breast tumor cell invasion.6 Knockdown of COPB2 led to cell apoptosis by inhibiting the RTK signaling cascade molecules in gastric cancer.21 In lung adenocarcinoma,7 patients with COPB2‐high had worse survival status than COPB2‐low. The gene discussed is CDH2; the disease is gastric cancer.