For example, Roesch et al23 reported that macrophages/glioma‐associated microglia (GAMs) tend to gather in tumor sites and generate an immunosuppressive tumor microenvironment which promote glioma invasion, growth, and angiogenesis.22, 24 Interestingly, one novel discovery of the present study is that COPB2 was involved in the immune microenvironment of glioma. The gene discussed is COPB2; the disease is central nervous system cancer.