Relative to normal clinical specimens, COPB2 indicated significant hyper‐expression in bladder, brain and central nervous system, breast, esophageal, head and neck, lung, lymphoma, sarcoma, and other cancers, but hypo‐expressed in leukemia (Figure 1A), suggesting that the high expression of COPB2 is common in various types of cancer. The gene discussed is COPB2; the disease is cancer.