We found that at a prior probability of 0.1 with an OR of 1.5, all the FPRP values were less than 0.2 (Supplementary Table S6, FPRP = 0.028, T vs. C; FPRP = 0.023, TT vs. CC; FPRP = 0.155, CT+TT vs. CC; FPRP = 0.022, TT vs. CC+ CT), indicating a noteworthy association between XPC rs2228000 and the risk of bladder cancer. The gene discussed is XPC; the disease is urinary bladder carcinoma.