DNMT3B and infection: The most remarkably VDR‐related infectious diseases include human immunodeficiency virus (HIV), tuberculosis (TB), and leprosy.47 In vitro studies by Chandel et al,50 showed that the infection of the previously activated T cells with HIV led to upregulation of DNA methyltransferases 3b (DNMT3B), increased promoter methylation of VDR (45%‐70%), and decreased VDR gene expression.