KRAS and colorectal carcinoma: KRAS regulates the expression of amino acid transporters including ASCT2, and glutamine uptake in KRAS‐mutated lung cancer cells.60 Furthermore, ASCT2 was upregulated in human CRC cells expressing mutant KRAS as compared with cells expressing wild‐type KRAS. 61 Analysis of human CRC samples revealed a significant positive correlation between the KRAS mutation status and ASCT2 protein expression, and an association between tumor depth and ASCT2 expression.25 These findings suggest that regulation of the expression and function of ASCT2 is closely related to the KRAS mutation status.