MTOR and cancer: ASCT2 is often expressed together with L‐type amino acid transporter 1 (LAT1)/CD98hc (SLC7A5/SLC3A2), a heterodimeric antiporter that exchanges large neutral amino acids.48, 62, 63 Both transporters have been implicated in cancer growth and mTOR signaling in many studies.63, 64 ASCT2 was proposed to take up glutamine, which then acts as an exchange substrate to accumulate leucine via LAT1/CD98hc.