This idea is consistent with the negative result of the study of Kim et al, looking for SCN1B variants in a cohort of DS patients29 as well as with the finding of neuronal pathfinding deficits in Scn1b null mice at postnatal day 10 prior to seizure onset.30 Thus, we propose that the term, “early infantile DEE,” is more appropriate than EIEE, which is classically used in patients with a severe early onset epilepsy and profound developmental delay. Here, SCN1B is linked to Global developmental delay.