BUB1 and urothelial carcinoma: By contrast, urothelial carcinomas subtypes with a poor prognosis display high expression of late cell cycle genes, including CDK1/cyclin B complex and its activators such as CDC25 family genes, and genes related to chromosome segregation and cell division such as BUB1, CDC20, and CENP (Sjodahl et al, 2012; Hedegaard et al, 2016).