High levels of co‐expression of p‐TFCP2L1 and CDK1 were associated with aggressive clinicopathological features, such as high tumor grade (P < 0.001) and frequent muscularis propria invasion (P = 0.041), distant metastasis (P = 0.040; Table 1), and cancer‐specific death (P < 0.001; Fig 4A). Here, TFCP2L1 is linked to cancer.