The VPS34‐p150‐beclin‐1 complex serves as a binding partner for several proteins, such as Atg14, to promote autophagy.32, 33 Enhancing the interaction between VPS34 and beclin‐1 is capable of promoting autophagy.34, 35 Our data illustrated that 14‐3‐3ζ overexpression enhanced the binding of VPS34 and beclin‐1 and further triggered autophagy in HCC cells. The gene discussed is ATG14; the disease is hepatocellular carcinoma.