Hypoxia up‐regulated 14‐3‐3ζ, beclin 1, phospho‐beclin 1S295 and LC3II levels (Figure S1) and down‐regulated p62 expression in HCC‐LM3 and CSQT‐2 cells (Figure 2A,B). The gene discussed is BECN1; the disease is hepatocellular carcinoma.