Data from GEPIA revealed a positive correlation between YWHAZ and BCEN1. Furthermore, our in vitro results demonstrated that 14‐3‐3ζ bound to and stabilized phospho‐beclin 1S295 in HCC‐LM3 and CSQT2 cells (Figure 6) and induced autophagy in these cells to resist CDDP cytotoxicity. The gene discussed is YWHAZ; the disease is hepatocellular carcinoma.