In an independent cohort of 54 primary NB tissues, the transcript levels of p200 CUX1, but not of CASP, were higher than those in normal fetal adrenal medulla (P < 0.05, Appendix Fig S1A), especially in cases with poor stroma (P = 0.0002) or advanced INSS stages (P = 0.007), without association with MYCN amplification (P = 0.56, Appendix Fig S1B). The gene discussed is MYCN; the disease is neuroblastoma.