Elevated circ‐CUX1 promotes the aerobic glycolysis, growth, and aggressiveness of NB cells by binding to EWS RNA‐binding protein 1 (EWSR1) and facilitating its interaction with MYC‐associated zinc finger protein (MAZ), resulting in MAZ transactivation and transcriptional alteration of CUX1 and other genes associated with tumor progression, suggesting circ‐CUX1/EWSR1/MAZ axis as a therapeutic target for aerobic glycolysis and NB progression. This evidence concerns the gene EWSR1 and neuroblastoma.