Thus, the bone marrow microenvironments of MDS → OL (AML‐MRC) and de novo AML were found to be completely different from the normal functions of niche cells.31 In MDS bone marrow, CD34‐positive/c‐kit‐positive cells are generally located in proximity to CXCL12‐positive cells and express the BCL‐2 protein, resulting in the suppression of apoptosis. This evidence concerns the gene KIT and acute myeloid leukemia.