Another study showed that CBX7 is a prognostic biomarker in glioma patients and induces cell-cycle arrest through downregulation of cyclin E.17Furthermore, expression of CBX7 is correlated with poor prognosis in ovarian clear cell adenocarcinoma patients, thyroid cancer.15, 18 In line with these reports, CBX7 overexpression is associated with better relapse-free survival of breast cancer patients.19 Here, CCNE1 is linked to central nervous system cancer.