Typical APL is characterized by recurrent PML-RARA expression, but up to now, to our knowledge, eleven cases with RARG dysregulation have been identified (Such et al., 2011; Ha et al., 2017; Liu et al., 2018; Miller et al., 2018; Qin et al., 2018; Chen et al., 2019; Luo et al., 2019; Zhang et al., 2019b) (Figure 2). The gene discussed is RARA; the disease is acute promyelocytic leukemia.