For patients without a matched related donor or a 10/10 matched unrelated donor, the decision between using multiple mismatched cord units, a mismatched unrelated donor, a haploidentical donor or to consider gene therapy (where available, e.g., for X-SCID, ADA-SCID, WAS, X-CGD, and in development for other diseases including AR-CGD and CD40L deficiency) remains difficult, in part due to the relatively limited experience of all these modalities in older patients with PID. The gene discussed is CD40LG; the disease is hyperinsulinemic hypoglycemia, familial, 4.