Similarly, TP53BP1 (cluster 3) has conditional essentiality in cell lines having mutation in TP53 (cluster 2) with survival advantage in lung cancer patients, and POLD1 (cluster 3) has conditional essentiality in cell lines having mutation in BRCA2 (cluster 1) and survival advantage shown in skin cancer patients. The gene discussed is POLD1; the disease is skin neoplasm.