TP53 and cancer: From the correlation analysis of pan-cancer wide enrichment scores (ssGSEA) as shown in Figure 2B, we observed exclusive pattern of enrichments between the DDR pathways from three groups; one consisting of pathways related to double strand break repair (group 1; enriched in cluster 1), one consisting of pathways related to late-stage cell cycle checkpoints (G2/M), Fanconi anemia and mismatch repair (group 2; enriched in cluster 3), and the other one consisting of single strand break repair and p53 dependent or independent DNA damage response (group 3; enriched in cluster 2).