From our findings, we showed that there are indeed potential SL relationships between genes from different clusters, and their co-inactivation can be lethal to the tumor cells (as seen in Figure 5, from RNAi screening data, e.g., CHEK2 and PARP1, TP53 and TP53BP1, BRCA2 and POLD1). Here, TP53BP1 is linked to neoplasm.