The study of serum cytokines in melanoma reported that the concentrations of several factors (IL-1α, IL-1β, IL-6, IL-8, IL-12p40, IL-13, G-CSF, MCP-1, MIP-1α, MIP-1β, IFN-α, TNF-α, EGF, VEGF, and TNF-RII) were significantly higher in patients with high-risk resected melanoma compared to those of healthy donors. The gene discussed is IL1B; the disease is melanoma.