To explore the effect of miR-622 on the migration and viability potential of breast cancer cells, we overexpressed miR-622 in MDA-MB-231 cells via transfection of the miR-622 agomir and stable N.C. Thirty-six hours after transfection, RNF8 protein level alterations were first verified by western blot. The gene discussed is RNF8; the disease is breast carcinoma.