By comparing these 25 genes with those that were differentially expressed in invasive breast cancer (BRCA), we found that three genes, HIST2H2BE, RGS4, and RAB10, were included in the intersection (Supplementary Figure 5); therefore, the miRNA-target axis formed by miR-622 and these genes might be involved in BRCA. The gene discussed is H2BC21; the disease is invasive breast carcinoma.