In the present study, we focused on miR-622, a non-coding microRNA located in the q31.3 arm of human chromosome 13 NC_000013.11 that is involved in the formation and progression of many common cancers, such as gastric cancer (25), lung cancer (27), liver cancer (28, 43), glioblastoma (44), colorectal cancer (43), and acute myeloid leukemia (AML), by acting as a tumor suppressor by targeting ING1, HIF-1α, MAP4K4, YAP1, and RB1. The gene discussed is RB1; the disease is colorectal cancer.