Despite their recent discovery, some evidence suggests that circRNAs are implicated in angiogenesis (e.g., circRNA-MYLK) and many cardiovascular diseases, such as atherosclerosis (e.g., circR-284), myocardial infarction (e.g., ciRS-7), and coronary artery disease (CAD) (e.g., circ_0124644), among others (107, 108). This evidence concerns the gene MYLK and coronary artery disorder.