CTLA4 and cervical carcinoma: We found that the majority (over 60%) of PD-1+TIGIT+2B4+Tim-3+KLRG-1–CTLA-4– CD8 TILs from all (5/5) of the poorly differentiated cervical cancer samples displayed an advanced T-cell differentiation phenotype and that only a small fraction (20%) displayed intermediate T-cell differentiation phenotypes (Figure 6A).