TIGIT and cervical carcinoma: Conversely, the majority (60%) of PD-1+TIGIT+2B4+Tim-3+KLRG-1–CTLA-4– CD8 TILs from most (4/5) of the moderately differentiated cervical cancer samples displayed an intermediate T-cell differentiation phenotype, and a minor fraction (40%) displayed advanced T-cell differentiation phenotypes (Figure 6B).