We identified PD-1+TIGIT+2B4+Tim-3+KLRG-1–CTLA-4– and PD-1+TIGIT+2B4+Tim-3–KLRG-1–CTLA-4– as dominant shared subsets of CD8 TILs in 64 cancer patients (4 with esophageal cancer, 11 with gastric cancer, 12 with colorectal cancer, 7 with breast cancer, 10 with lung cancer, 10 with kidney cancer, and 10 with cervical cancer) (Figures 3A–G). Here, CTLA4 is linked to cancer.