RictorMyf5-Cre ablation in BAT causes higher mitochondrial activity and protects mice from high-fat diet-induced obesity and hepatic steatosis at thermoneutrality, while in acute cold challenge, RictorMyf5-Cre mice show significantly induced Ucp1 expression in BAT [107]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.