KLRK1 and central nervous system cancer: In another combination treatment approach, Lawrence Lamb (University of Alabama, Birmingham, USA) demonstrated that using Temozolomide (TMZ) to induce upregulation of NKG2D ligands on human glioma tumors, in a xenogeneic glioma tumor mouse model, drastically increased the efficacy of adoptively transferred GMP-grade γδ T cells efficacy.