Annexin-V/propidium iodide staining showed that non pre-activated PBL incubation for 72 h with 0.1 μg/mL scDb at an E:T ratio of 5:1 can bypass the sTRAIL resistance of cancer cells, achieving a good apoptosis percentage in all melanoma cell lines tested, independent of their susceptibility profile to sTRAIL (Figures 1B,C). This evidence concerns the gene ANXA5 and cancer.