Importantly, a pre-incubation with an antiTRAIL-R2 mAb, which competed for the same binding site of scDb on TRAIL-R2 (Figure 2B), was sufficient to revert the growth inhibitory effect on melanoma cell lines obtained by PBLs in the presence of the bispecific antibody, further confirming the specificity of the effect seen (Figure 2C). This evidence concerns the gene TNFRSF10B and melanoma.