With regard to pathways down-regulated with HDAC6 inhibition, there were 59 pathways with Z scores ≤ −2 and p-values ≤ 0.05; pathways associated with immune signaling, B cell signaling, myeloid inflammatory pathways and phagocytosis—all pathways previously demonstrated to be important in the pathogenesis of human SLE (31–33). Here, HDAC6 is linked to systemic lupus erythematosus.