In endothelial cells, although, IFN-α/β has been shown to promote endothelial proliferation in vitro (28), and reduce intracellular NO generation and impair fibrinolysis of HUVECs in vitro (29), the precise impact of IFN-α/β on endothelial function in the context of bloodstream infection or sepsis is not clear. The gene discussed is IFNA1; the disease is Sepsis.