Whereas, IL-1 and TNF-α pathways have been investigated as a strategy to improve sepsis outcome, by studying the impact of humoral signals from leukocytes on endothelial cells, we observed a stronger enrichment of IFN-α/β and IFN-γ signaling than IL-1 and TNF-α signaling in endothelial cells. The gene discussed is IFNG; the disease is Sepsis.